INOSITOL THERAPY IN TREATING SUBFERTILE WOMEN AND ADOLESCENT GIRLS WITH PCOS

PROBLEM STATEMENT: PCOS is not merely a common gynaecological and endocrinological disorder affecting 5 - 10% of women in their reproductive age group but it is also very much prevalent in adolescent girls and can be seen in perimenopausal women. Although hyperandrogenism and infertility that PCOS causes are distressing to young women, its metabolic sequelae plaque the individual in terms of morbidity and mortality. No treatment regime with insulin sensitizer like metformin, o/c pills, ovulation induction, or anti-androgens like flutamide are satisfactory due to their limitations.

METHOD: A total of 407 cases diagnosed with PCOS were recruited from different gynaecologists after informed consent and ethics approval. Diagnosis of PCOS was made by using the Rotterdam criteria 2003 (RC), There are 4 PCOS phenotypes used in diagnosing criteria, hyperandrogenism, oligo anovulation, and polycystic ovary. MI /DCI are inositol isomers that are abundant in ovaries and follicular fluids and have distinct roles in insulin signalling and follicular development. In this study myoinositol 4000mg and 4 mg of folic acid were used for six months in treating adolescent girls and women of childbearing age group, in both lean and obese women.

RESULTS: In total 35 women conceived out of 200 women of childbearing age and the pregnancy rate is 15.1% which is at par. 147 women experienced a significant improvement in their menstrual circles. Out of 207 adolescent girls 164 experienced regular circles, improvement in skin conditions like acne and hirsutism, BMI, RBS, and fasting insulin levels following MI treatment. No significant adverse effects of MI were reported except 4 cases of flatulence and 3 cases of nausea.

CONCLUSION: Inositol can be used as a safe and alternative approach in the treatment of sub fertile women and adolescents with PCOS.

ABBREVIATIONS

1. PCOS : Polycystic Ovarian Syndrome

2. MI : Myo Inositol

3. DCI : Di Crino Inositol

4. RBS : Random Blood Sugar

5. BMI : Body Mass Index

DISCLOSURE OF INTEREST: There is no disclosure of interest