WHAT IS THE OPTIMAL CUT OFF VALUE OF NUMBER OF EGG DONATION FROM SAME EGG DONOR LIFE TIME?

Problem Statement: Different country regulations required from single stimulation to maximum 6 stimulations for egg donors in lifetime. This is a balance between efficacy of the ART program and donor safety.

Methods:In this single center, 4 years of retrospective study was included oocyte donors (n=96) with repeating cycles of ovarian stimulation (COS). We evaluated the concordance between the follicle-to-oocyte index (FOI), number of oocytes retrieved, maturation rate (MR), utilization rate (UR) and the numbers of attempts from 1st to 6th. The mean age of the patients in this study was represented in dynamics (SD) from 1st COS program 23,2 (3,2) to 27,8 (3,7) years during final 6th cycle.

Results:The mean number (SD) of mature oocytes retrieved was non significantly different and raised from the 1st attempt –18,46 (8,89), to 5th - 22,03 (10,16), with slightly decreasing during 6th COS – 21,55 (12,06). MR and UR indicators had a fluctuating picture of the dynamics of values. They either increased or decreased from one cycle to another. Mean values of MR was the lowest after 3rd COS (81%) and the highest – 4th COS (84%). UR dynamic was quite similar with lowest value after 1st cycle (12,0%) and the maximum 17,9% after 6th COS program. FOI parameter was measured within the values of 73,82 – 81,02, i.e. min value 73,82 (16,40) was observed after second stimulation cycle and max value – after fifth (mean = 81,02±18,26). These changes between cycles parameters were found to be not significantly different (p>0.05). Regarding egg donation cycle outcome for recipients (age average 34,57) attempt 1st -3rd gave 96,14% fertilization rate, %66,89 used blastocysts rate and %60,77 clinical pregnancy rate. Recipients ( age average 33,19) attempt 4th- 6th gave %94.17 fertilization rate, %64,09 used blastocysts rate and %63,19 clinical pregnancy rate.

Conclusion:The controversial dynamic of the changes of the embryological parameters and COS outcomes in the same donor’s pool after repeated stimulation cycles with no statistically observed differences can be ground for making a positive decision both personally by the donor and the IVF specialist.