There was investigated the ability to the interaction between phosphatidylcholine's and cardiolipine's bi-sphere of the physiologically active compound's (PAC) membranes belong to the classes of phenylalkylamines (doputamine, verapamil), dihydropyridins (BAY-K-8644, nifedipine) and analogs of crown-ethers (carbicil, diol).
By the methods of microcallorimetry and spectrophotometry it was established the opportunity of PAC to form the complexes with lipid bi-sphere of model membranes. For the combinations with negative inotropic activity the kind of lipid bi-sphere polarity's changing depends on their concentrations in bi-sphere: within physiological concentrations the polarity of pyrene's surroundings is improved and the charge of surface of electronic field is increased, when the concentration is being increased the polarity environment and the charge of surface of the electronic field are decreased, that is conditioned by structural modification of the bi-sphere surface due to their influence.
This is able to result the confirmative changes of the direct located protein molecules of regulatory enzymes and ions channels as well as to the modulation their signal and transport functions.
Keywords: phosphathydilcholine's, bi-sphere of membranes, phenylalkylamines, dihydropyridins, crown-ethers, interaction.
