By new method of synthesis between ftorotane, as fluorosubstituted syntone and 5(6)-substituted uraciles under phase-transfer conditions in alkaline medium catalysed by the 18-crown-6-complex new bis-adducts of uraciles were synthesised.
New their molecular complexes with bacterial lectines: Bacillus subtilis 668 IMV и Bacillus polymyxa 102 KGU were obtained. The main pharmacological index of the bis-adducts and their molecular complexes – toxicity were obtained. The purity has been tested by method of thin-layer and gas-liquid chromatography. It was discovered that compounds, which synthesized apply to little toxic preparations: LD50 from 515 mg/kg up to 125 mg/kg. These investigations shown that molecular complexes of bis-adducts and bacterial lectines has a not hight level of toxicity - LD50 from 635 up to 125 mg/кg.
The nearest analogical compound of the bis-adducts which synthesized are antitumour preparation 5-FU. A strongly antitumour effect of compound N(1),N(1’)-(2"-bromo-2"-chloroethenyl)-bis-(5-fluorouracile) which synthesized on Lymphosarcoma Plissa tumour with growth relaxation of tumour mass 75,3% has been registered.
Therefore the bis-adducts and their molecular complexes are potential phisiological active compounds has a perspective future as potential antitumour preparations for medicines.
Key words: 5-FU, ftorotan, lectin, crown-ether, toxicity, antitumour activity.
