Trans-Arterial Microembolization in Inflammatory Bowel Disease - Proof of Concept in a Porcine Model
2Gastroenterology, Shaare Zedek Medical Center, Israel
Background:
Pathologic neo-angiogenesis is a recognized a pain modulator in chronic inflammatory diseases of the musculoskeletal (MSK) system. There is robust evidence specifically in osteoarthritis of the knee with trans-arterial microembolization (TAME) already common clinical practice. There is histologic basis for chronic inflammation associated neo-angiogenesis in inflammatory bowel disease (IBD), and angiogenesis inhibitors are included in the medical armamentarium targeting IBD. To date, there is no published data using TAME in chronic inflammatory conditions outside of the MSK system.
Methods:
A single adult Yorkshire Pig will have baseline endoscopy, biopsy and mucosal injection of phenol compound in order to induce chronic inflammation. 2.5 weeks after initial endoscopy, repeat endoscopy and biopsy of the affected colon will be performed. TAME will be performed at same time, targeting the affected colon segment. 1-2 weeks post TAME, repeat endoscopy, biopsy and necropsy will be performed.
Results:
Initial results are expected in first week of October 2026, prior to the ISRA Conference. These can be presented as a first report.
Conclusions:
TAME for treatment of IBD represents an exciting potential opportunity to expand use of TAME outside of the MSK system.