Resveratrol (trans-3, 4, 5-trihydroxystibene) has been considerable interest in its potential benefit for human health, since it can be used as antioxidant, anti-inflammatory, and anti-cancer agent. However, the pool in vivo bioavailability of resveratrol due to its rapid metabolism is being considered as a major obstacle in translating its effects in humans. Thus, this study was purposed to investigate resveratrol-loaded microspheres as a colon specific carrier with high bioavailability. Different concentration (0.5 and 1%) of alginate-calcium chloride (CaCl2) microspheres were developed by encapsulator which equipped with a different size of nozzle (150, 200 and 300 um). The mean particle size of microspheres was between 100 and 200 um, and FTIR spectrum showed the polyelectrolyte interaction between alginate and CaCl2. The release profiles and encapsulation efficiency depended on the concentration of polymers used as wall materials and bead size. Observations from this study revealed that alginated-CaCl2 microspheres enhanced its bioavailability as a result of increased solubility and sustained releasing of resveratrol.
