Riboflavin (vitamin B2) plays an important role in biochemical redox reactions in humans and animals. It works as an antioxidant and is essential for the health of skin, hair, eyes, and liver.
Microemulsions are clear, stable, isotropic mixtures of oil, water, and surfactant, which are capable of solubilizing different active matter.
In the present work we are solubilizing riboflavin phosphate in various unique dilutable selected microemulsions of oil-in-water. Presented system allows the controlled release of riboflavin. The permeation and target delivery of these formulations into human organs and across the blood-brain barrier (BBB) are of our interest.
Structural aspects of the empty system in comparison to those loaded with the riboflavin have been studied using advanced analytical tools, such as cryo-TEM, PFGS-NMR, SAXS, and macro-techniques such as DSC, viscosity and electrical conductivity.
Guest molecule loading capacity (up to 4.4 wt%), structural changes (unique microemulsion transformation) and release profiles (within minutes to hours) of the riboflavin, in three different formulations (zero to 10 wt% oil) to aqueous phase will be presented.
Prof. Nissim Garti garti@vms.huji.ac.il
