Circulating Uric Acid as a Marker of Coronary Arteries Calcification in Patients with Ischemic Chronic Heart Failure with Preserved Left Ventricular Pump Function

Objective: to evaluate the interrelation between serum uric acid and artery calcification in asymptomatic coronary artery disease subjects.
Design and Methods: 126 subjects with previously documented asymptomatic coronary artery disease were enrolled in the study.
Results: Mean value of serum uric acid level was 23.84 mmol / L (95% confidence interval [CI] = 15.75 – 31.25 mmol / L). In multivariate Cox regression analysis, the results showed that serum uric acid levels (odds ratio [OR] = 1.42; 95% CI = 1.20 – 1.82; P <0.001), osteopontin (OR = 1.14; 95% CI = 1.12–1.25; P <0.001), osteoprotegerin (OR = 1.45; 95% CI = 1.20–1.89; P <0.001), type 2 diabetes mellitus (OR = 1.41; 95% CI = 1.20–1.72; P <0.001), and total cholesterol (OR = 1.13; 95% CI = 1.10–1.22; P <0.001) were factors that independently associated with coronary artery calcification. The Cox models suggested that high quartile of serum uric acid level is very significant in predicting Agatston score index.
In conclusion, we suggested that high quartile of serum uric acid level (cutoff point equaled 35.9 mmol / L) was a very significant predictor of coronary calcification in subjects with ischemic chronic heart faiklure with preserved left ventricular ejection fraction.