Intima-media thickness in patients with chronic kidney disease (CKD) correlates with the duration and stage of renal disease .
Materials and Methods: The study included 85 pts - 47 F and 38 M , mean age 60.1 ± 9.88 divided into 2 groups: I gr.- 45 pts , with hypertension, diabetes and eGFR > 90 ml / min, CKD 0-1 st., mean age 58.9 ± 8.13 and group II - 40 patients with diabetes, hypertensive and GFR 30-60 ml / min, CKD- 3 st. mean age 62.8 ± 10.7 , and 20 healthy volunteers - average age of 48,8 ± 5,2 , GFR > 90 ml / min and RR < 130/80 mmHg - controls for IMT. Classic cardiovascular risk factors(CVRF) : duration of hypertension and diabetes , dyslipidemia , BMI were reported in both groups.Determination of GFR is based on creatinine clearance CrCl in ml / min. IMT were measured for both common carotid arteries in all 85 pts and in 20 controls.
Results: Patients in gr.II had significantly longer duration of diabetes and hypertension with comparable BMI and total cholestrol compared with group I. Healthy controls had normal IMT. Diabetics of both groups had significant increase in IMT, compared with normal controls (0.73; 0,79/ 0.59 mm). Pts in gr. II witn CKD 3 st. had statistically higher IMT, compared with gr. I - (0,73 mm ± 0,05 / 0,79 mm ± 0,10, p <0,01) . Factors that are important for IMT given by correlation analysis were; age, duration and severity of CKD, duration of hypertension and diabetes. Regression analysis demonstrated a link between IMT and the level of GFR Decrease in CrCl of 1 ml / min,increases IMT with 0,002 mm.
Conclusion: The presence of CKD with impaired renal function along with classic CVRF are related to thickening of the intima-media.
