Background: Antibodies to Oxidized LDL are associated with oxidative stress and atherogenesis. The purpose of this study was to evaluate the relation between diastolic dysfunction and the levels of the anti – oxidized LDL antibodies.
Patients and methods: This was a single center prospective study.
One thousand consecutive patients undergoing coronary angiography were enrolled. Diastolic dysfunction was assessed by Doppler echocardiography in 508 patients. It was defined significant if pseudonormal or restrictive pattern was observed.
Results: Patients with diastolic dysfunction were more likely to be older (71.9 vs 68.7 years, p=0.001), be female (35.0% vs 25.6%, p=0.032), to have chronic kidney disease (28.6 % vs 16.2%, p=0.001) and lower ejection fraction (44.5% vs 50.5%, p<0.0001). These patients were also more likely to be hypertensive and diabetic. There was no difference neither in rates of urgent catheterization due to the acute coronary syndrome, nor in the extend of the coronary artery disease.
Patients with significant diastolic dysfunction were more likely to have significantly elevated (more than 3 OD units) antibodies to oxidized LDL (25.1% vs 16.9%, p=0.028).
In the logistic regression model, which included age, gender, hypertension, diabetes, renal failure, diastolic dysfunction and ejection fraction; only presence of the significant diastolic dysfunction was independently associated (OR=5.87, p=0.018) with elevated levels of the anti – oxidized LDL antibodies.
Conclusions: Diastolic dysfunction is significantly associated with elevated levels of anti-oxidized LDL antibodies, which are markers of oxidative stress and atherogenesis.
