Transthoracic Ultrasonography in Pulmonary Alveolar Proteinosis – Case Report

Natalia Buda 1 Maria Porzezińska 2 Magda Osowicka 2 Wojciech Kosiak 3 Robert Rzepko 4 Elżbieta Radzikowska 5 Jan Marek Słomiński 2 Ewa Jassem 6
1Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdansk
2Department of Pneumonology, Medical University of Gdansk
3Department of Ultrasound Diagnostic and Biopsy at the Department of Pediatrics Hematology, Oncology and Endocrinology, Medical University of Gdansk
4Department of Pathomorphology, Specialistic Hospital in Prabuty
53-rd Department of Pneumonology, National Tuberculosis and Lung Diseases Research Institute in Warsaw
6Department of Allergology, Medical University of Gdansk

A pulmonary alveolar proteinosis (PAP) is a rare disease characterized by an accumulation of surfactant components in lung alveoli. A diagnosis of PAP was made on a basis of open lung biopsy which revealed intraalveolar eosinophilic material with coarse granularity, few macrophages and lymphocytes. The substance was PAS positive and compatible with surfactant. The lung interstitial architecture was well preserved with no lymphocyte infiltration, granuloma or fibrosis of the alveolar septae. The picture was compatible with PAP.  In diagnosis and monitoring of the disease high resolution computed tomography (HRCT) is usually used. Unfortunately, repeated exposure to CT scanning may be associated with an increased risk of radiation. We present a patient in whom repeated transthoracic lung ultrasonography (TLUS) brought parallel to HRCT data in assessing PAP extent. It may indicate that TLUS might be potentially a relevant tool in monitoring of PAP.









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