Objective: The aim of the current study was to evaluate the prognosis of patients with low AMH levels (0.2-1 ng/ml) and extremely low AMH levels (≤0.2 ng/ml).
Design: Retrospective study
Materials and Methods: Between January 2006 and June 2011 we studied 181 women with an initial AMH levels of ≤ 1 ng/ml, undergoing IVF-ICSI (769 cycles). Serum AMH levels were measured at initial presentation and prior to all following treatment cycles.
Results: Seventy patients (249 cycles, mean age 37.8±5 years) had extremely low AMH levels (<0.2ng/ml), whereas 111 patients (519 cycles, mean age 38.4±4.6 years) had low AMH levels (0.21-1.0 ng/ml). Number of oocytes retrieved per cycle, fertilized oocytes and number of embryos for transfer were significantly lower in the extremely low AMH levels group compared to the low AMH levels group ( P<0.003). There was no difference in clinical and ongoing pregnancy rates per cycle, as well as in clinical and ongoing pregnancy rates per patient between the extremely low AMH group and the low AMH group (6.8% and 4.4% vs. 7.1% and 4.4% ; 23% and 16% vs. 30% and 20%, respectively). Multivariable regression analysis revealed no significant difference in ongoing pregnancy rates per cycle between the two groups. Cumulative pregnancy rates of 20% were observed following five cycles for both groups of patients.
Conclusions: Patients with extremely low AMH level (≤ 0.2 ng/ml) demonstrate low but reasonable ongoing pregnancy rates with a linear growth of cumulative pregnancy rate.
