Objective:.To determine the prevalence of placental complications in patients conceived through donor versus autologous oocytes.
Methods:A retrospective cohort study including two groups of patients who conceivedthrough in vitro fertilization using:1)donor oocyte (n=139) and 2) autologous oocyte (n=126). Only singleton gestations were included .The rate of placental complications including preeclampsia, gestational hypertension and intra uterine growth restriction (IUGR) was compared between these two groups.
Results:The women who conceived using donor oocytes were older compared to women who conceived using autologous oocytes (median maternal age 45 vs 41, p<0.01). The rate of hypertensive diseases of pregnancy including gestational hypertension and preeclampsia was significantly higher in ovum donor recipients compared with women conceived with autologous oocytes (25% vs 10%, p<0.01). Similarly, the rate of IUGR was also higher among patients conceived through oocytes donation although it did not reach statistical significance (9.3% vs 4%, p=0.08). When maternal age was restricted to ≤45 years, the rate of hypertensive diseases of pregnancy remained significantly higher among ovum donor compared to autologous oocyte recipients (22% vs 10%, p=0.02). Adjustment for maternal age, gravidity, parity and chronic hypertension revealed that oocyte donation was independently associated with higher rate of hypertensive diseases of pregnancy (P=0.01).
Conclusions:Patients conceived through oocytes donation have an increased risk for placental complications of pregnancy. These findings support the "immunological theory" suggesting that immunological intolerance between the mother and the fetus may play an important role in the pathogenesis of preeclampsia.
