Introduction: Follicular size at administration of recombinant human chorionic
gonadotropin (rHCG) and timing and duration of GnRh ant. administration, are amongst
the several factors that may affect the success of GnRH ant. protocol, however, their
optimal characteristics are controversial.
Aim: To find the factors that affect the success rate of GnRH
ant. protocol in in- vitro- fertilization(IVF) treatment.
Materials and Methods: Retrospective cohort study. 181 patients who underwent
IVF cycle in 293 cycles in GnRH ant. protocol in the years 2011-2013.Factors estimated: duration
of antagonist, estradiol (E2), progesterone, leading follicle size at
antagonist start and at time of rHCG. Main outcomes: number of eggs, embryo
quality and pregnancy rate.
Results: Mean age was 34.8
± 6 years, primary and secondary infertility rate of 38% and 62% respectively.
Maximum follicular size mean was 19±1.4mm; mean egg number was 7.5 ± 5.4, and
mean best embryo grade 3±0.5. Factors affected numbers of eggs were
E2 level and leading follicle at day of antagonist. Follicular diameter size at day of rHCG,
affected the embryo quality and optimal
follicle size was less than 18
mm. Only age, number and quality of embryo were found as
predictors of pregnancy
Conclusion: E2 level and leading follicle size at the day of
antagonist start are predictors for the number of eggs as well as follicle
maximal size and type of medication. Only age, number and quality of embryo
were found as predictors of pregnancy.
