Introduction: Following the instruction of implementation of the Israeli Egg Donation Law in February 2012, our center has indwelled the guidelines in May 2012 and started with the first treatment cycle in November of the same year.
Aim: To evaluate the outcome of the egg donation (ED) program performed according to the demands of the new local egg donation law.
Material and methods: Treatment protocol was an antagonist cycle: Menogon starting on day 3 adding Orgalutran once the leading follicle was of 12-14 mm diameter. Triggering by 0.2 mg Decapeptyl was administered when the 2-3 leading follicles reached 17-18 mm. Each recipient received at least 4 mature (MII) oocytes. All recipients were prepared with oral contraceptives or progestatives for synchronization and started on the 3rd withdrawal bleeding day, Estradiol Valerate. Once the endometrium reached ≥6mm and the donor was on her triggering day, vaginal micronized progesterone was started. Normally two embryos were transferred.
Results: During November 2013 to January 2014 twelve donors were treated in 14 cycles. Mean age was 30.4±4.01y (range 22-34y). Four donors were at the age of 34y. One of them started her treatment twice and developed in both cycles a leading follicle of 17 mm diameter already on the 5th stimulation day which consequently brought to single follicle. Those treatments were cancelled. Two other donors (22y and 34y) had 4 and 5 oocytes, respectively, with bad morphology. The mean age of the 22 recipients was 42.4± 4.96y. The mean number of donated eggs per recipient was 6.3±1.29. Transfer of 2.3±0.55 embryos established seven (32%) clinical pregnancies. An additional pregnancy was achieved after transferring thawed embryos in 2 thawing cycles. Nine recipients have frozen embryos or blastocysts available for their next trial. The donor per recipient ratio was 1:1.83.
Conclusion: Taking into consideration the limitations made by the Egg Donation Law: donor's mean age is relatively advanced, the received number of oocytes per recipient is reasonable and so is the success rate. The creation of egg bank will facilitate the procedure and may also increase the pregnancy rate.
