The talk will focus on the synthesis, characterization and applications of porous organosilicates, silicates, to be used for in vitro and in vivo imaging but also as components for special type of hydrogels. The use of ordered mesoporous silica will be illustrated as containers for molecules and for delivering PNA and DNA inside HeLa cells. The fate of the silica particles will be discussed and in particular their accumulation in specific location in the cells will introduce our newest finding of porous systems able to disintegrate upon an external stimulus. Their delivery properties and their destruction kinetics shown with an example. I will discuss the use of small porous nanoparticles, as constituent of hydrogel, to generate hybrid scaffold used as matrix for 3D growth of cells. The pores of the particles can be used as food reservoir and we have demonstrated that cells in such conditions can live several days.
1. A. Bertucci, H. Lülf, D. Septiadi, A. Manicardi, R. Corradini, L. De Cola, Adv. Healthcare Mater., 2014
2. F. Fiorini, L. De Cola to be submitted
decola@unistra.fr
