Magnetic Hyperthermia demonstrated its relevance in in vitro and in vivo studies using iron oxide
nanoparticles and polymer composites; however, due to biological constraints on the amplitude (≤ 15kA.m -1)
and frequency (100kHz-1MHz) of AC magnetic field, materials with high value of specific loss power are required for clinical application in order to reach therapeutic temperatures of about 43˚C.
The research deals with preparation of iron oxide nanoparticles and polymer composites thereof with a complex of magnetic,
AC magnetic field energy absorption and rheological properties for the magnetic hyperthermia.
Magnetic iron oxide nanoparticles are prepared by coprecipitation method in aqueous medium under certain reaction conditions.
The possibility of magnetic nanoparticles delivery, uniform distribution and retention of in the tumour using polymeric
composite material will be presented. The initial components (silicone polymers with vinyl- and hydride- side groups and
plasticizer) and their relative concentrations are selected so that the material stays liquid during 20 minutes, providing the opportunity for transcatheter transportation and filling of the tumour vascular system. After this induction period of polyaddition, reaction is taking place forming a soft emboli leading to the occlusion of the tumour´s blood vessels. Iron oxide
magnetic nanoparticles uniformly distributed in the composite provide its rapid heating under exposure to the AC magnetic field. The designed polymer magnetic material could be used in the arterial embolization treatment method.
