The design of new non-immunogenic polymeric material platforms that contain functionalities that can either trigger a natural healing process, promote degradation, lead to controlled release of therapeutics is of great importance. We have developed a new family of functional, biodegradable coatings that can be covalently bound to the substrate (i.e. the stent) while also providing for covalent attachment to subsequent coating layers. These multilayer coatings are designed to bear a primer polymer layer composed of epoxide functional groups that can be attached to a variety of metallic and ceramic surfaces after oxidation treatments. The primer polymer has other degrees of chemical functionality, such as alkenes, for the direct attachment of the second coating that can be processed using thiol-ene click chemistry. The bilayer system displayed good adhesion to the substrate and showed a controlled release of the incorporated dye.
