Objective: To study an angiographic status, N-terminal pro-brain natriuretic peptide (Nt-proBNP) level and compliance in stable angina patients (pts).
Material and methods: 151 pts (men) 54,8±0,7 years old divided in 3 groups according ACTION trial design were investigated. The 1st group was consisted of 43 men with uncomplicated angina without significant lesions of coronary artery, the 2nd group included 47 angina pts with history of percutaneous coronary intervention last 1-3 years, and the 3rd group included 61 men with angina after previous myocardial infarction last 1-3 years. Methods included echocardiography, coronarography, laboratory research, Nt-proBNP levels determination.
Results: Structure and functional parameters of the heart as well as coronary artery state were more lesion in pts after previous myocardial infarction, and after angioplasty. Nt-proBNP main values were 0,28±0,07, 0,28±0,09 and 0,53±0,08 ng/ml in 1st, 2nd and 3rd groups accordingly, and were significant higher in 3rd group pts. Factors determining Nt-proBNP and correlated with its levels were age, degree of coronary stenosis, left-atrium-size, left-ventricular end-diastolic- and end-systolic size, left-ventricular myocardium mass index, and ejection fraction. Multivessel lesion registered more often in 3rd group pts, where main stenosis level was 71,7±2,5% (in 1st group - 36,8±1,6%, and in 2nd group – 78,1±2,0%). The main number of lesion arteries for one patient was 1,7±0,1, 2,0±0,1 and 2,5±0,1 at the 1st, 2nd and 3rd groups accordingly (р1-3<0,0001, р2-3=0,001). Compliance to complex event prevention therapy (ACEI, antiplatelet drugs, and statins) was highest at the 2nd group. The minimum compliance in all groups pts was registered for statins.
Conclusion: Coronary artery lesion as well as Nt-proBNP levels rise were expressed in patient with myocardium infarction history. Compliance to complex event prevention therapy was highest in pts with history of percutaneous coronary intervention.
