Coronary disease is the most frequent disease and cause of mortality in women. Aim: Study gender effects in acute anterior ST-elevation myocardial infarction (STEMI) and primary percutaneous intervention (PPCI) on coronary artery and myocardial perfusion and left ventricular systolic function. Methods: 184 consecutive patients, 33 women, with acute anterior STEMI treated by PPCI were evaluated. TIMI flow, myocardial blush grade (MBG) in the left anterior descending (LAD) coronary artery, ST-Elevation resolution, LAD blood velocity parameters, diastolic deceleration time (DDT) and left ventricular systolic function parameters, early and late post-PPCI, were measured. Results: Women were older (69±11.9 Vs 58.2±11.9, p<0.0001), had lower weight (73.2±14.1 vs 85.2±15.2kg, p<0.005), less smokers (61.9% vs 84% ,p<0.05), less diabetics (28.6% Vs 42.7% ,p<0.05), but more hypertension (79.3% vs 63% ,p=<0.05), with. Time intervals till PPCI were similar. TIMI grades before and after PPCI were similar. MBG>1 before PPCI was found in 20% of women and 9.4% in men, p<0.05; however after PPCI, MBG in men and women were similar. Women had larger extent of ST-elevation resolution 2.5±2.12mm while men had 1.375±1.19mm, p600 msec, while 43.3% of men, p600msec. Left ventricular systolic function in women was similar to that in men.
