Optical Properties and Biomedical Applications of Novel Plasmonic Core-Shell Nanoparticles

Xiulong Jin School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China Li Lin School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China Min Xiong School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China Yuqing Zhang School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China Ni Kong School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China Hongfei Yu School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China Haiyan Li School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China Hongchen Gu School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China Jian Ye School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China

Plasmonic core-shell nanoparticles offer a unique platform to obtain interesting optical properties and to combine multifunctions in a single particle, which shows great potential in biomedical field. In this talk, we will present two types of novel plasmonic core-shell nanoparticles in our very recent work: superparamagnetic nanoshells (SNs) and nanomatryoshkas (NMs).

Triggered by an external magnetic field, SNs form self-assembled particle chains and exhibit a number of near- and far-field optical responses including the Fano resonance and the super- and sub-radiant modes [1]. SNs particle chains also act as an ideal substrate for surface-enhanced Raman scattering (SERS) due to the strong plasmon coupling effect. Recently we have used SNs for two-photon luminescence-based vascularization imaging, magnetic separation, stimulating proliferation and SERS-based differentiation of cells [2, 3].

Quantum plasmon effects emerge recently with the advances in fabrication techniques of structures (typically, nanoparticle dimers) with ultrafine sub-nm nanogaps [4-7]. Gold NMs with a 0.7 nm gap inside synthesized recently in our group can act as another type of suitable structural model for experimental and theoretical investigation of the tunneling plasmon effect. Some preliminary extinction spectra and calculation results will be shown. The insights acquired from this work may help us further develop novel quantum plasmonic devices and reconsideration of design rules for the fabrication of plasmonic nanostructures. In addition, gold NMs show promising applications in SERS-based lateral flow immunoassay for sensitive, reproducible and multiplexed biomolecular detections due to the significant and reproducible SERS properties.

References

[1] M. Xiong, X. Jin, J. Ye, in preparation.

[2] X. Jin, H. Li, S. Wang, N. Kong, H. Xu, Q. Fu, H. Gu, J. Ye, Nanoscale, 2014, 6, 14360.

[3] X. Jin, H. Yu, N. Kong, H. Gu, J. Chang, H. Li, J. Ye, in preparation.

[4] C. Ciraci, R. T. Hill, J. J. Mock, Y. Urzhumov, A. I. Fernandez-Dominguez, S. A. Maier, J. B. Pendry, A. Chikoti, D. R. Smith, Science, 2012, 337, 1072.

[5] K. J. Savage, M. M. Hawkeye, R. Esteban, A. G. Borisov, J. Aizpurua, J. J. Baumberg, Nature, 2012, 491, 574.

[6] S. F. Tan, L. Wu, J. K.W. Yang, P. Bai, M. Bosman, C. A. Nijhuis, Science, 2014, 343, 1496.

[7] R. Esteban, A. G. Borisov, P. Nordlander, J. Aizpurua, Nature Communications, 2012, 3, 825.

yejian78@sjtu.edu.cn