IMAGING ORGANIC CRYSTALLIZATION IN AQUEOUS MEDIA


Yael Tsarfati Haim Weissman Shaked Rosenne Boris Rybtchinski
Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel

Organic crystals are of primary importance in pharmaceuticals, functional materials, and biological systems. Nevertheless, the understanding of organic crystallization mechanism is still limited. Understanding the transformation from “Non-classical” Prenucleation phases into crystals is a key challenge. In this study a Perylene Diimide (PDI) crystallization, within aqueous solution, is studied by optical spectroscopy and cryogenic electron microscopy, in order to address this challenge. Direct imaging of evolving prenucleation phase reveals a fascinating complexity of a nonclassical crystallization path, providing new insights into organic crystallization mechanism.

Yael Tsarfati
Yael Tsarfati
The Weizmann Institute of Science